Real Madrid's clash vs Sporting de Gijon is going to take place at the El Molinon stadium, in Asturies.
Isco picked out the top corner at the end of a jinking solo run in the 17th minute after Duje Cop had opened the scoring for relegation-threatened Sporting in equally memorable style.
Isco kept Real Madrid's LaLiga title charge on track with a virtuoso performance to rescue a 3-2 win at struggling Sporting Gijon.
Ramos sent his header off target from a corner before Isco finally broke through Sporting's tiring rearguard when he drilled a right-foot shot past Cuellar which nestled just inside the post. "But we had many chances to score, so in the end it is a deserved result".
Reflecting on the display, in which Isco boasted a team-high 95% pass accuracy, Zidane said (via Goal): "Isco played a great game. We need everyone and everyone responds".
This victory sees Los Blancos with a six-point lead in the standings ahead of Barcelona's match against Real Sociedad at 2:45 p.m. ET.
Madrid, which has a game in hand, hosts Barcelona next round in a "clasico" match that will go a long way to determining the league champion.
With only a slender lead over Leicester City in their Champions League tie, Atletico coach Diego Simeone will also be tempted to make changes and will hope striker Kevin Gameiro is available to play.
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Real can't afford to rest on their laurels as they now prepare for Tuesday's Champions League quarter-final second leg against Bayern, a fixture made simpler by last Wednesday's 2-1 turnaround in Germany.
The calculated risk taken by Zidane came close to backfiring.
Real hit back three minutes later as Isco curled home a fine effort into top corner to level matters for the visitors.
Real Madrid boss, Zinedine Zidane, has confessed to the press that his squad is facing a challenging moment during right now due to the team's weak defensive line.
Whether all this equates to a Barca backlash depends on which Enrique side turns up, although unconvincing displays against Leganes and Deportivo following both legs against PSG suggests we're unlikely to see the hosts at their best.
Sporting went back ahead through a header by Mikel Vesga, who had already set up Cop's opener, which looped over the goalkeeper five minutes after halftime.
Morata scored nine minutes later, heading home Danilo's cross, and Madrid pressed for a victor with Isco robbed of the ball when poised to shoot after another bewitching dribble and substitute Marcelo drilling wide.