A spokesman for the UN's World Health Organization on Friday (12 May) confirmed that one person, who tested positive to the virus in a laboratory, had died in the Central African nation.
In 2014, more than 11,300 people were killed in the worst-ever outbreak of the virus in West Africa, majority in Guinea, Sierra Leone and Liberia.
World Health Organization made the announcement on Friday, May 12 following the deaths of three people from the dreaded disease since April 22.
Bas-Uele province, the area of the outbreak, rests in a remote northern stretch of the DRC, on the border with the Central African Republic.
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"The Likati health district is in a remote area, but contact tracing is essential to contain the epidemic in its focus; the DRC can rely on very experienced health workers for this objective", Dr. Yokouidé Allarangar, the WHO representative in the DRC, said in a statement Friday.
"Our country must confront an outbreak of the Ebola virus that constitutes a public health crisis of global significance", the ministry said.
Among the 5,837 people who received the vaccine, no Ebola cases were recorded 10 days or more after vaccination.
Forty-nine people were killed in the country's last outbreak of Ebola in 2014.
"We were able to estimate the efficacy of the vaccine as being 100 percent in a trial", Ira Longini, a biostatistician at the University of Florida, told NPR's Michaeleen Doucleff last December.