Two German tourists were stabbed to death and four other foreigners were wounded in an attack at a hotel in the Egyptian Red Sea resort of Hurghada.
The attacker appears to have swam from a nearby public beach to gain access to the resort, officials say.
The injured tourists were immediately admitted to a local hospital.
Tourists were reportedly stabbed in the face, neck and feet by the attacker.
The motive for his attack was is not known, but ISIS does operate within Egypt and has targeted tourists in the past.
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The 2016 attack was one of the incidents that affected tourism in the last two years, leading to a severe decline in revenues generated from Egypt's tourism sector. The news agency AP confirmed the victims' nationality.
The Zahabia and El Palacio hotels in Hurghada, one of Egypt's most popular holiday resorts, around 400 kilometres south of the capital Cairo, both have their own private beach.
The attack came after five police officers were shot dead in Cairo's twin city of Giza when suspected Islamic militants opened fire on their vehicle early on Friday morning.
An IS-affiliated group, "Sinai Province", claimed responsibility for the aeroplane crash.