The 32-year-old Lewis, from The Woodlands just north of Houston, won her 12th LPGA Tour title and first since June 2014, ending a frustrating stretch that included 12 runner-up finishes.
Every shot she hit at a flagstick Sunday, every putt she poured in at the Cambia Portland Classic did more than take her a step closer to the trophy at Columbia Edgewater Country Club.
"I was feeling great", said Moriya. Take me to the finish line.
Henderson, who played last week in front of the home crowd at the CP Women's Open in Ottawa, Canada, didn't show any signs of fatigue. "But you've got to get a lot of things right to get that to go your way". She hit a good lag putt and when the three-footer that was left went in, Lewis had won and the money was going to Houston.
The 32-year-old American looked well on course to be able to hand over the United States dollars 195,000 (£150,000) first prize when she started the day with a three-shot lead over the chasing pack and then birdied the opening two holes. "My caddie (Travis Wilson) has been here way more times than anybody probably in this field, and so I think we have an advantage as far as knowing the golf course". "So just to have him here and get to share the win with him was pretty special".
A number of PGA Tour players have pledged money to the Houston flood victims as well. She added two more on the back nine (10 and 18) while only having just one bogey on 16.
Prior to the tournament she signalled her intentions via twitter, and was nearly overcome with emotion as she came to terms with what she'd accomplished.
"I kind of resigned to the fact that whatever was going to happen was going to happen", Lewis said.
"You have to hit shots".
He had flown to from Houston to Portland Sunday to surprise her.
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Henderson eagled on the par-4 11th hole.
She was leading by three with 18 holes to play and closed with a three under par 69 to win by one.
"I'm just really excited".
Lewis rebounded from a bogey at the par-3 16th with a 5-foot birdie putt at the hard par-4 17th.
"It was a little bit up and down today", said Henderson.
South Korean players' winning streak on the LPGA Tour has ended at five.
American Brittany Altomore shot a 66 and is alone in fourth place at 205.
Henderson had a 74 to drop into a tie for 13th at 8 under.
Miyazato announced last week that she has chosen the year's final major, the September 14-17 Evian Championship in France, as her last event.