The favorite Karolina Pliskova qualified for the quarter-finals of the worldwide of the United States, with easily of the American Jennifer Brady 6-1, 6-0 in just 47 minutes on Monday.
Against an undoubtedly tricky opponent capable of playing well above her unseeded status, this was an impressive performance from Vandeweghe, who successfully backed up her win over Agnieszka Radwanska with 16 winners and six aces today.
"I think it's great to have three, maybe hopefully four tonight, Americans in our American Grand Slam", Vandeweghe said before Keys took the court.
The 25-year-old Czech tennis star Karolina Pliskova secured herself a spot in the last eight stages in NY after dismantling Jennnifer Brady in a bit under 50 minutes of play.
Brady won just 22 points in the entire match and the Czech Republic ace felt the home talent was a bit overawed by the occasion.
It was Safarova who got off to the best start in the tiebreak, securing a mini-break in the opening point, though quickly lost it as Vandeweghe began to sense victory. The Czech will have to reach the final to guarantee that she stays atop the rankings.
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Pliskova has candidly reflected on her struggles thus far and the pressure that accompanies her world ranking. "If there's some all-American matchups in the rest of the tournament, I think that says really good things about women's tennis".
Pliskova said: "Today I was much better". Now comes a set of quarterfinals with fewer of the usuals than usual, and with No. 1 Rafael Nadal already booked after his 6-2, 6-4, 6-1 trouncing of Alexandr Dolgopolov on Monday.
"Well, obviously I think it's the speed of the shots, but otherwise, I would not really put me and her together". "My energy dropped. Once I got broken in the third, I just kept telling myself: 'Just try to figure it out".
Brady, who also went to the fourth round in the Australian Open, held serve only once against the sharp, hard-hitting Pliskova. I was lucky that I had an awesome crowd and atmosphere. "Of course, going out there I was a bit nervous", Brady said.
Keys and Vandeweghe are trying to join fellow Americans Venus Williams and Sloane Stephens into the women's quarters.
With Wimbledon champion Garbine Muguruza knocked out on Sunday night by Petra Kvitova, this now appears a golden chance for Pliskova to win her maiden grand slam title. Even if she just miss like 5 meters out, she doesn't care, so it's different.