Up to 50 people were killed and some 87 others wounded on Thursday in a vehicle bomb and a gunfire attacks near the city of Nasriyah in Iraq's southern province of Dhi Qar, a provincial medical source told Xinhua.
"The total death toll of the victims reached 50 persons, while 87 others were wounded", the health department said in a statement.
He warned that the death toll could rise as numerous wounded were in serious condition.
Security sources said the attackers were disguised as members of the Hashed al-Shaabi paramilitary units which have fought alongside the army and police against the terror groups.
Iraqi and Kurdish security officials say the Sunni militants are likely to wage a guerrilla war in Iraq after their self-proclaimed caliphate in Mosul collapsed.
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There were no immediate claims of responsibility for the deadly attacks, but such assaults bear the hallmarks of those carried out by the Islamic State.
The attack occurred as Iraqi forces battled to defeat ISIS terrorists in areas under their control. The road targeted by jihadists is in southern Iraqi province Dhi Qar, heavily populated by Shi'ite Muslims. Isis claimed the twin slayings through its propaganda agency Amaq.
Police sources said some police officers had died in the checkpoint attack, but the toll from that incident remained unclear.
The group's only other stronghold is Hawija, in Kirkuk province some 300 kilometres north of Baghdad.